Publicity towards the glucuronide metabolite is 35 to forty moments larger than exposure towards the dad or mum drug. In vitro facts advise that hydromorphone in clinically pertinent concentrations has small opportunity to inhibit the action of human hepatic CYP450 enzymes which include CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.The desk can not be used